Abstract
The prooxidant role of malaria parasites and chloroquine an antimalaria is well established. The antioxidant role of ascorbic acid and folate administered alone or as adjuvant therapy during malaria treatment in a
research series is highlighted in this review. It was observed that oxidative stress is implicated in the pathogenesis of malaria and the oxidative assault may be aggravated by chloroquine, which was at some point a frontline antimalarial drug. Owing to the established antioxidant roles of vitamins, the
administration either as mono, combined or as adjuvant therapy ameliorated malaria-induced oxidative assault. Supplementation with antioxidants represents a promising and enhanced therapeutic approach in malaria treatment. This review emphasized the beneficial roles of ascorbic acid and folate as adjuvants in malaria therapy.